Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1258)
Related Products (1258)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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Terflavoxate
0 ImagesCat. No.: HY-106415CAS No.: 86433-40-1Terflavoxate is a flavone derivative with spasmolytic properties. Terflavoxate has Ca2+-antagonistic effect is mainly responsible for Terflavoxate smooth muscle relaxant properties. Terflavoxate has the potential for overactive detrusor research.
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Teludipine hydrochloride
0 ImagesCat. No.: HY-101621CAS No.: 108700-03-4Synonyms: GR53992B; GX1296BTeludipine is a lipophilic calcium channel blocker.
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Tiapamil hydrochloride
0 ImagesCat. No.: HY-101674CAS No.: 57010-32-9Synonyms: Ro 11-1781Tiapamil hydrochloride is a calcium channel blocker.
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ABT-639 hydrochloride
0 ImagesCat. No.: HY-101616CAS No.: 1235560-31-2ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
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Nexopamil racemate
0 ImagesCat. No.: HY-101727CAS No.: 116759-35-4Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro.
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Iganidipine
0 ImagesCat. No.: HY-101685CAS No.: 119687-33-1Iganidipine is a Ca2+ antagonist.
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SM-6586
0 ImagesCat. No.: HY-19062CAS No.: 103898-38-0SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
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TDN345
0 ImagesCat. No.: HY-101669CAS No.: 134069-68-4TDN345 is a Ca2+ antagonist, used for the treatment of vascular and senile dementia including Alzheimer's disease.
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Teludipine-d6
0 ImagesCat. No.: HY-101621SCAS No.: 1246833-02-2Teludipine-d6 is the deuterium labeled Teludipine hydrochloride. Teludipine is a lipophilic calcium channel blocker.
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Nefiracetam (Standard)
0 ImagesSynonyms: DM9384 (Standard); DZL-221 (Standard)Nefiracetam (Standard) is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca2+ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research.
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Trimebutine (Standard)
0 ImagesTrimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
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2,6-Dibromophenol (Standard)
0 Images2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda).
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N106 (Standard)
0 ImagesCat. No.: HY-110273RCAS No.: 862974-25-2N106 (Standard) is the analytical standard of N106 (HY-110273). This product is intended for research and analytical applications. N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research.
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(S)-Azelnidipine
0 ImagesCat. No.: HY-167168CAS No.: 722455-09-6(S)-Azelnidipine is a calcium channel (Calcium Channel) blocker and the S-isomer of Azelnidipine, with potential for use in cardiovascular disease research.
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Mirogabalin (Standard)
0 ImagesCat. No.: HY-12650RCAS No.: 1138245-13-2Synonyms: DS5565 (Standard)Mirogabalin (Standard) is the analytical standard of Mirogabalin. This product is intended for research and analytical applications. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
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Pinaverium bromide (Standard)
0 ImagesPinaverium bromide (Standard) is the analytical standard of Pinaverium bromide. This product is intended for research and analytical applications. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients.
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BX430 (Standard)
0 ImagesCat. No.: HY-110237RCAS No.: 688309-70-8BX430 (Standard) is the analytical standard of BX430 (HY-110237). This product is intended for research and analytical applications. BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.
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S‐Y048
0 ImagesCat. No.: HY-184965CAS No.: 2020058-38-0S-Y048 is an orally active OXE receptor-selective antagonist with picomolar-level IC50 values (0.02-30 nM) and pIC50 values of (10.47-10.81) against human receptors. S-Y048 selectively blocks the 5-oxo-ETE signaling pathway, inhibits actin polymerization, calcium mobilization, leukocyte migration, as well as allergen-induced leukocyte infiltration in skin and lung tissues, and reduces mucin-producing bronchial epithelial cells. S-Y048 undergoes benzyl, N-methyl and α-hydroxylation reactions to form metabolites in monkeys. S-Y048 can be used in research related to asthma, allergic asthma, allergic eosinophilic diseases, atopic dermatitis and allergic rhinitis.
